The protein receptor found in the lungs sticks to the virus and pulls it away from the target cells. University of Sydney scientists have discovered a protein in the lung that blocks SARS-CoV-2 infection and forms a natural protective barrier in the human body. This protein, the leucine-rich r
Immunofluorescent staining shows expression of the new SARS-CoV-2 Spike-receptor LRRC15 in post-mortem lung tissue section from individual with COVID-19. Credit: The University of SydneyUniversity of Sydneyinfection and forms a natural protective barrier in the human body.
The University study is one of three independent papers that reveal this specific protein’s interaction with COVID-19. Like ACE2, LRRC15 is a receptor for coronavirus, meaning the virus can bind to it. But unlike ACE2, LRRC15 does not support infection. It can, however, stick to the virus and immobilize it. In the process, it prevents other vulnerable cells from becoming infected.
LRRC15 is present in many locations such as lungs, skin, tongue, fibroblasts, placenta and lymph nodes. But the researchers found human lungs light up with LRRC15 after infection.
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