A study has identified a potential mechanism behind the delusions and hallucinations experienced by individuals with schizophrenia. An international team of researchers, including Sofya Kulikova, a Senior Research Fellow at HSE University-Perm, discovered that ketamine's role as an NMDA receptor in
Ketamine is a powerful anesthetic drug that is used in medicine for surgical procedures and pain management. It is also used as a recreational drug for its mind-altering and hallucinogenic effects. In recent years, ketamine has gained attention for its potential as a rapid-acting treatment for depression, anxiety, and other mental health disorders. However, its use for depression is still considered off-label and more research is needed to fully understand its effects and safety.
A drug called ketamine can induce a mental state similar to psychosis in healthy individuals. Ketamine inhibits NMDA receptors involved in the transmission of excitatory signals in the brain. An imbalance of excitation and inhibition in the central nervous system can affect thePre-stimulus beta and gamma frequencies on cortical and thalamic recordings are significantly higher under ketamine conditions compared to saline conditions. Credit: Yi Qin et all.
Beta oscillations are brainwaves in the range of 15 to 30 Hz, and gamma waves are those in the range of 30 to 80 Hz. These frequencies are believed to be critical for encoding and integrating sensory information. The post-stimulation time lapse of 200–700 ms is long enough to encode, integrate and perceive the incoming sensory signal. The observed decrease in the power of sensory stimulus-induced oscillations can be associated with impaired perception.
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