As they age, both mice and humans tend to become less active and lose muscle mass and strength. Scientists led by Johan Auwerx at EPFL have recently discovered that aging mice have an accumulation of ceramides in their muscles. Ceramides are commonly used in skincare products and are a type of sphin
golipid, a class of fat molecules that perform various cellular functions rather than being used for energy production.
Next, the scientists wanted to see whether reducing ceramide overload could prevent age-related decline in muscle function. They treated old mice with ceramide blockers, such as myriocin and the synthetic blocker Takeda-2, and used adeno-associated viruses to block ceramide synthesis specifically in muscle. The ceramide blockers prevented loss of muscle mass during aging, made the mice stronger, and allowed them to run longer distances while improving their coordination.
Finally, the scientists looked at whether reducing ceramides in muscle could also be beneficial in humans. They examined thousands of 70-80-year-old men and women from Helsinki and discovered that 25% of them have a particular form of a gene that reduces the gene products of sphingolipid production pathways in muscle.
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