How can researchers profile post-COVID syndromes among distinct SARS-CoV-2 variants? medrxivpreprint KingsCollegeLon SARSCoV2 COVID19 PostCOVIDSyndrome Variant
By Shanet Susan AlexAug 2 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers profiled post-coronavirus disease syndrome throughout various severe acute respiratory syndrome coronavirus 2 variants.
According to the authors of the present investigation, no available research compares the symptom pattern of PCS among COVID-19 vaccination status and distinct SARS-CoV-2 variants. In addition, no studies sought to characterize the PCS by reporting the modeling of longitudinally acquired symptoms in a time-series data format.
The different symptom profiles for PCS patients across SARS-CoV-2 variants and vaccination status during infection time were identified using clustering assessment of time-series data. Subsequently, clusters were characterized by symptom duration, prevalence, demographics, and comorbidities or preceding conditions. Furthermore, the team looked into how PCS clusters influenced the lives of impacted individuals utilizing an independent research sample with supplementary data from 140 people.
A cardiorespiratory symptom cluster was discovered among all variants. Central neurological disorders were the subject of a second cluster, and instances with the most debilitating and severe multi-organ symptoms were associated with a third cluster. There were not more than two distinct phenotypes of gastrointestinal symptoms per virus strain. An independent research sample validated the existence of the three major clusters and evaluated their functional influence.
Conclusions The researchers claimed that the current study was one of the initial large-scale investigations to establish a PCS symptom cluster among adults in an unsupervised manner.
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