A study in published BMCSportsSciMedRehabil finds that age, fat mass and physical activity level are associated with cardiovascular risk factors in patients with inflammatory joint disease. The authors suggest the need for continued exercise intervention.
]. Aforementioned studies have employed various measures of CRF and there is a need to replicate study results using the CRF criterion method. Uncovering associates of CRF in IJD may aid healthcare practitioners in identifying patients that can benefit from a CRF assessment to provide a more comprehensive assessment of CVD risk.
The primary aim of this paper was, therefore, to investigate factors that may associate with CRF in a contemporary IJD population. We hypothesized that we would uncover associations between classical CVD risk factors, disease activity and CRF in patients with IJD. The second objective was to evaluate CRF in patients with IJD relative to reference data from the general population, and explore potential differences in demographic, cardiovascular and IJD-related factors in patients with normal versus low levels of CRF.The data underlying this paper stems from baseline visits in the ExeHeart trial ; a randomized controlled trial with a primary aim to evaluate the effect of high-intensity interval training on CRF in patients with IJD [].
Patients were recruited from the Preventive Cardio-Rheuma Clinic, Center for treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Norway. Patients presenting with an IJD diagnosed by rheumatologist, age 18–70 years, body mass index 18.5–40, ability to walk unaided for ≥ 15 min and Norwegian or English fluency were eligible for inclusion.
] and prior participation in high-intensity interval training ≥ 1/week in the past 3 months. Baseline study visits were carried out from August 2021 to August 2022.Medical background information including IJD diagnosis and co-morbidities were collected from the patient’s medical record. CRF was assessed by a cardiopulmonary exercise test on a treadmill. A modified Balke [] continuous ramp protocol was applied with initial speed individualized to the patient’s preference.
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Associations between long-term fine particulate matter exposure and hospital procedures in heart failure patientsBackground Ambient fine particulate matter (PM2.5) contributes to global morbidity and mortality. One way to understand the health effects of PM2.5 is by examining its impact on performed hospital procedures, particularly among those with existing chronic disease. However, such studies are rare. Here, we investigated the associations between annual average PM2.5 and hospital procedures among individuals with heart failure. Methods Using electronic health records from the University of North Carolina Healthcare System, we created a retrospective cohort of 15,979 heart failure patients who had at least one of 53 common (frequency | 10%) procedures. We used daily modeled PM2.5 at 1x1 km resolution to estimate the annual average PM2.5 at the time of heart failure diagnosis. We used quasi-Poisson models to estimate associations between PM2.5 and the number of performed hospital procedures over the follow-up period (12/31/2016 or date of death) while adjusting for age at heart failure diagnosis, race, sex, year of visit, and socioeconomic status. Results A 1 μg/m3 increase in annual average PM2.5 was associated with increased glycosylated hemoglobin tests (10.8%; 95% confidence interval=6.56%, 15.1%), prothrombin time tests (15.8%; 95% confidence interval=9.07%, 22.9%), and stress tests (6.84%; 95% confidence interval=3.65%, 10.1%). Results were stable under multiple sensitivity analyses. Conclusions These results suggest that long-term PM2.5 exposure is associated with an increased need for diagnostic testing on heart failure patients. Overall, these associations give a unique lens into patient morbidity and potential drivers of healthcare costs linked to PM2.5 exposure.
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Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK BiobankCoffee and tea drinking are thought to be protective for the development and progression of neurodegenerative disorders. This study aims to investigate associations between coffee and tea consumption with macular retinal nerve fiber layer (mRNFL) thickness, a marker of neurodegeneration. After quality control and eligibility screening, 35,557 out of 67,321 United Kingdom (UK) Biobank participants from six assessment centers were included in this cross-sectional study. In the touchscreen questionnaire, participants were asked how many cups of coffee and tea were consumed daily on average over the last year. Self-reported coffee and tea consumption were divided into four categories including 0 cup/day, 0.5–1 cups/day, 2–3 cups/day, and ≥4 cups/day, respectively. The mRNFL thickness was measured by the optical coherence tomography (Topcon 3D OCT-1000 Mark II) and automatically analyzed by segmentation algorithms. After adjusting for covariates, coffee consumption was significantly associated with an increased mRNFL thickness (β=0.13, 95% CI=0.01~0.25), which was more prominent in those who drank 2~3 cups coffee per day (β=0.16, 95% CI=0.03~0.30). The mRNFL thickness was also significantly increased in tea drinkers (β=0.13, 95% CI=0.01~0.26), especially for those who drank more than 4 cups of tea per day (β=0.15, 95% CI=0.01~0.29). The positive associations with mRNFL thickness, indicating that both coffee and tea consumptions had likely neuroprotective potentials. Causal links and underlying mechanisms for these associations should be explored further.
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Associations Between Ambient Air Pollution and Cognitive Abilities from Midlife to Early Old Age: Modification by APOE Genotype - IOS PressBackground: Fine particulate matter (PM2.5 ) and nitrogen dioxide (NO2 ) measures of ambient air pollution are associated with accelerated age-related cognitive impairment, and Alzheimer’s disease and related dementias (ADRD). Objective: We examined
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Evictions and Infant and Child Health OutcomesThis systematic review without meta-analysis synthesizes and assesses data from studies examining the associations of eviction exposure with infant and child health outcomes.
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Telehealth Coverage Debate Still Unfolding in Mass. LegislatureMassachusetts doctors and health care associations embraced legislation Tuesday that could make telehealth a more permanent option for patients who are in too much pain to visit a provider’s office in person or cannot coordinate travel logistics. Bills filed by Rep. Marjorie Decker and Sen. Adam Gomez (H 986/S 655) would require insurance reimbursement parity for all telehealth services, going…
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Motor cortex functional connectivity is associated with underlying neurochemistry in ALSObjective To identify structural and neurochemical properties that underlie functional connectivity impairments of the primary motor cortex (PMC) and how these relate to clinical findings in amyotrophic lateral sclerosis (ALS). Methods 52 patients with ALS and 52 healthy controls, matched for age and sex, were enrolled from 5 centres across Canada for the Canadian ALS Neuroimaging Consortium study. Resting-state functional MRI, diffusion tensor imaging and magnetic resonance spectroscopy data were acquired. Functional connectivity maps, diffusion metrics and neurometabolite ratios were obtained from the analyses of the acquired multimodal data. A clinical assessment of foot tapping (frequency) was performed to examine upper motor neuron function in all participants. Results Compared with healthy controls, the primary motor cortex in ALS showed reduced functional connectivity with sensory (T=5.21), frontal (T=3.70), temporal (T=3.80), putaminal (T=4.03) and adjacent motor (T=4.60) regions. In the primary motor cortex, N-acetyl aspartate (NAA, a neuronal marker) ratios and diffusion metrics (mean, axial and radial diffusivity, fractional anisotropy (FA)) were altered. Within the ALS cohort, foot tapping frequency correlated with NAA (r=0.347) and white matter FA (r=0.537). NAA levels showed associations with disturbed functional connectivity of the motor cortex. Conclusion In vivo neurochemistry may represent an effective imaging marker of impaired motor cortex functional connectivity in ALS. Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as online supplemental information. Requests for data should be made to the corresponding author, SK, who is the director of CALSNIC.
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