Motor cortex functional connectivity is associated with underlying neurochemistry in ALS

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Motor cortex functional connectivity is associated with underlying neurochemistry in ALS
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Researchers pinpoint neurochemical marker linked with loss of motor function in ALS ualberta

The following sections describe the statistical analyses performed in this study:: A univariate full factorial GLM was used in SPM12 to examine group differences in FC of the PMC with other brain regions. Diagnosis was included as a factor in the GLM in addition to the CALSNIC centre of data acquisition. Age, sex and number of years of education had no influence on FC differences, so these variables were removed from the model to allow for an increase in the degrees of freedom.

Relationship between structural, neurochemical and functional characteristics and the rate of functional decline : The revised ALS Functional Rating Scale , a 12-question self-administered questionnaire , was used to calculate the rate of functional decline in patients with ALS using the formula /symptom duration. To ascertain the relationship between the rate of functional decline and MRI measures in the PMC, two sets of correlations were performed:

Bivariate Pearson’s correlational analyses between spectroscopy, diffusion measures and disease progression rate .Demographic and clinical characteristics of the sample All patients in our study had a confirmed diagnosis of ALS and were matched with healthy controls on the basis of age, sex and years of education. Patients had an average symptom duration of 26.7 months and a mean ALSFRS-R Score of 38.8/48, with 42 patients having limb-onset ALS. Foot tapping frequencies were significantly reduced in ALS compared with healthy controls .

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