Airpollution may increase risk of dementia, complicated by genetics ucsandiego TheLancet IOSPress_STM
[*] Correspondence to: Carol E. Franz, PhD, University of California San Diego, 9500 Gilman Drive, MC 0738, La Jolla, CA 92093, USA. Tel.: +1 858 822 1793; E-mail:Background:Fine particulate matter and nitrogen dioxide measures of ambient air pollution are associated with accelerated age-related cognitive impairment, and Alzheimer’s disease and related dementias .
ctors, and the moderating role of apolipoprotein E genotype in the understudied period of midlife. Methods:Participants were ∼1,100 men in the Vietnam Era Twin Study of Aging. Baseline cognitive assessments were from 2003 to 2007. Measures included past and recent PM2.5 and NO2 exposure, in-person assessment of episodic memory, executive function, verbal fluency, and processing speed, and APOE genotype. Average baseline age was 56 years with a 12-year follow-up.
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