Long before Alzheimer's disease is diagnosed, once-trusty proteins start to knot together in the brain in a process that may be hastened by poor sleep.
in levels of amyloid-beta have been noted in the cerebrospinal fluid of healthy adults, but these oscillations appear to be disrupted with age, the largest risk factor for Alzheimer's disease.
However, making the direct connection between circadian rhythms and the activity of immune cells tasked with cleaning up amyloid proteins has eluded scientists thus far.In this new study, researchers led by biological scientist Jennifer Hurley of Rensselaer Polytechnic Institute studied immune cells called macrophages, which are known to migrate into the brain in late-stage Alzheimer's disease.
In lab-grown cell cultures observed under a microscope, these immune cells – derived from genetically modified mice with altered circadian clocks – went about cleaning up fluorescently-tagged amyloid-beta proteins on a daily cycle. As levels of cell-surface proteins called heparans went up, the clearance of amyloid-beta proteins slowed.
But the immune cells promptly lost their rhythm when their circadian clock was disturbed, suggesting cell-surface heparans, and the protein-eating immune cells they regulate, fall under circadian control. "These data highlight that circadian regulation in immune cells may play a role in the intricate relationship between the circadian clock and Alzheimer's disease," the team
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Ex-NHL Player Ron Duguay Insists He’s Just ‘Friends’ With Palin After Holding Hands at Defamation TrialFormer New York Rangers star Ron Duguay took to the Manhattan federal courthouse steps on Thursday to announce to the world that his interest in Sarah Palin is strictly platonic.
Consulte Mais informação »
How Pete Davidson Is Supporting Kim Kardashian Amid Kanye West DramaA source tells ET that Pete Davidson 'has been playing with the idea of getting a place in Los Angeles' to be closer to Kim Kardashian.
Consulte Mais informação »
Cell studies suggest a way sleep loss may be linked to Alzheimer’sProtein plaques associated with Alzheimer's disease may build up in the brain if sleep is disrupted because this affects cells that normally destroy them, according to a study involving mouse immune cells
Consulte Mais informação »
Sting Hopes to Do a 'Good Job' Singing en Español at Premio Lo NuestroShould we call him Pica now? Sting is headed to Univision’s Premio Lo Nuestro later this month to premiere his new completely-in-Spanish single “Por Su Amor'
Consulte Mais informação »
Ice skating at the Winter Olympics continues with rhythm dance. Here's how to watch.Ice skating at the 2022 Beijing Winter Olympics continues with the rhythm dance portion of the ice dancing program. Here's how to watch, stream the events.
Consulte Mais informação »
Jeremy Giambi’s cause of death was suicide, coroner’s report saysFormer Major League Baseball player Jeremy Giambi died by a self-inflicted gunshot wound, according the Los Angeles County Medical Examiner’s coroners report.
Consulte Mais informação »