Protein plaques associated with Alzheimer's disease may build up in the brain if sleep is disrupted because this affects cells that normally destroy them, according to a study involving mouse immune cells
nobeastsofierce Science / Alamy Stock Photoon a circadian schedule and this could be affected by sleep loss, a study involving mouse cells suggests.
The circadian schedule is an internal clock that controls sleep and a vast array of other bodily processes on a roughly 24-hour cycle. Doctors have long observed that people with Alzheimer’s disease have sleep disturbances and circadian disruption, but it remains unclear the extent to which this disruption could be a cause for the condition itself.
Hurley and her team also identified a class of circadian-controlled proteins involved, called heparan sulphates, which Hurley thinks may signal to the macrophages when to clear away the plaques. These proteins control many processes, but are typically associated with inflammation. Understanding the timing and mechanisms of the macrophage plaque-clearing process could lead to new treatments for some of the symptoms of Alzheimer’s disease, says Hurley. The build-up of beta-amyloid plaques rises and falls in healthy brains, but this oscillation can stop as people get older, leading to more plaques. “Since we know that this oscillation goes away with time, perhaps we can boost that oscillation in Alzheimer’s patients,” says Hurley.
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