Understanding the adverse events profile of MVA-BN vaccine for Mpox JAMA_current Uni_Newcastle adverse events MVABN vaccine mpox Mpox
By Tarun Sai LomteMay 10 2023Reviewed by Lily Ramsey, LLM A recent study published in the Journal of American Medical Association evaluated adverse events following the Modified Vaccinia Ankara-Bavarian Nordic vaccination for mpox.
Accordingly, a 0.1 ml intradermal dose was recommended for pre-exposure prophylaxis and a 0.5 ml subcutaneous dose for post-exposure prophylaxis in a two-dose regimen four weeks apart. Demographic details and vaccination date/time were self-reported. Vaccinations were classified as subcutaneous if administered in the deltoid muscle and intradermal if injected in the forearm.
Related StoriesThe rate of adverse events was the highest after the first dose administered intradermally at 53% and the lowest after the second subcutaneous dose at 31%. Cardiorespiratory adverse events were rare. Individuals with atopic dermatitis reported the highest rate of adverse events. Adverse event rates were similar between immunodeficient individuals and those without chronic conditions.
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