The risk of adverse reactions when herbal medications are taken with cancer drugs Cancer AdverseDrugReaction HerbalMedicine SciReports ULBruxelles
By Dr. Liji Thomas, MDAug 24 2022Reviewed by Benedette Cuffari, M.Sc. Herbal medicines have remained popular antidotes used to treat a wide range of chronic conditions. Throughout the world, there has been a rising trend in mistrust of modern medicinal compounds, thus increasing the combined use of herbal therapeutics with other drugs, even for cancers. The VigiBase database reports possible adverse drug reactions and is supported by the World Health Organization .
All entries on VigiBase meeting these criteria were extracted and analyzed. Every entry with one ADR from one ACD and one herb interacting with each other, but not more than five therapeutics simultaneously, were included.The herbs examined included: Green tea is also implicated in anemia through reduced iron absorption by up to 99%, methotrexate toxicity by the inhibition of the organic anion transporting polypeptide 1A2 of which methotrexate is a substrate, and hepatotoxicity when used with other potentially hepatotoxic compounds.
Conversely, St. John’s wort, an effective antidepressant, is a strong CYP3A4 inducer and could weaken the effect of oral ACD that are substrates of this enzyme. This compound can also cause photosensitivity and, when used in combination with drugs like hypericin or temozolomide, can trigger optic neuropathy after radiation therapy.
The current study notes that just over 1,000 ADRs were found on the database, thus reflecting the low incidence of reporting with phytochemicals. Detailed reporting is essential to improve safety through measures to minimize the risk by educating professionals about the potential for drug interactions.
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