The genetics of resting heart rate and its connection to cardiovascular disorders NatureComms heartrate cardiovasculardisease cardiovascular heartrate restingheartrate
By Vijay Kumar MalesuAug 7 2023Reviewed by Sophia Coveney In a recent study published in Nature Communications, a group of researchers investigated the genetics behind resting heart rate and its impact on cardiovascular disease, correcting previous biases and providing novel insights into disease development.
Detailed genomic analysis was done, with each cohort subjected to rigorous quality control procedures. Genetic correlation analyses identified significant links with previous traits. Definitions of health conditions and longevity were collected, and exceptions were applied in certain cases. Blood pressure values were obtained and corrected for medication use. Detailed statistical analysis was carried out for functional outcomes, external cohort definitions, and genome-wide association studies. Replication analysis, quality control, regression analyses, and additional exclusions were done to enhance reliability.
Study results In the present study, the IC-RHR conducted a meta-analysis of RHR using 99 cohorts with 351,158 individuals and a GWAS on 484,307 UK Biobank subjects. This resulted in the analysis of 30,458,884 genotyped and imputed autosomal variants in 835,464 individuals, identifying 493 independent genetic variants.
The ECGenetics browser was used to explore the electrophysiological impact of RHR genetic variants, identifying 86 variants associated with a minimum of one ECG time point.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Similarities in gene expression between post-mortem and living human brainsSimilarities in gene expression between post-mortem and living human brains medrxivpreprint geneexpression gene expression postmortem human brains humanbrain brainhealth
Consulte Mais informação »
How does the circulating proteome influence brain health?How does the circulating proteome influence brain health? medrxivpreprint brainhealth brain health proteome
Consulte Mais informação »
Research develop a revolutionary toolkit to combat digital exclusionResearch develop a revolutionary toolkit to combat digital exclusion medrxivpreprint revolutionary toolkit digital exclusion digitalexclusion
Consulte Mais informação »
Understanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency statusUnderstanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency status medrxivpreprint COVID COVID19 SARSCov2 evolution immunodeficiency covidevolution
Consulte Mais informação »
Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsisRole of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis BMC_series macrophage exosomes tissueinjury sepsis M2macrophage neutrophil
Consulte Mais informação »
Exploring the safety of COVID-19 mRNA vaccines in the elderlyExploring the safety of COVID-19 mRNA vaccines in the elderly JAMANetworkOpen COVID19 covid SARSCoV2 mRNA elderly olderpersons research
Consulte Mais informação »