Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis BMC_series macrophage exosomes tissueinjury sepsis M2macrophage neutrophil
By Pooja Toshniwal PahariaAug 7 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the Journal of Biomedical Science, researchers investigate whether M2 macrophage-derived exosomes could prevent inflammation-associated damage during sepsis-associated acute lung injury by modulating abnormal polymorphonuclear neutrophil behaviors.
Macrophages are important mediators in influencing the outcome of the inflammatory response. This has increased interest among researchers in understanding the interaction between PMNs and macrophages. Related StoriesPeripheral blood mononuclear cells were isolated for macrophage cell culture. Celecoxib, a selective cyclooxygenase-2 inhibitor, was used to inhibit prostaglandin E2 expression in these cells.
The third International Consensus Definitions for Sepsis and Septic Shock were used to diagnose sepsis. Individuals below 18 years of age, pregnant women, and those with active bleeding, severe anemia, and undergoing chemotherapy were excluded from the analysis.
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