A study published in Immunity & Ageing discusses the potential utility of metformin to improve flu vaccine responses and immunological resilience in nondiabetic older adults. Further investigation with a larger sample size is required.
]. Combined with this, our study suggests that metformin may have additional utility for improvements in immunological resilience and vaccination responses in nondiabetic and nonprediabetic older adults. It is also possible that metformin may have more prominent immune benefits in older adults who are prediabetic, prefrail, frail, or have other comorbidities that were excluded from this pilot trial.
The study protocol was approved by the Institutional Review Board at the University of Connecticut Health Center and registered at ClinicalTrials.gov . All study participants provided written informed consent to participate in the study. Subjects were screened for eligibility, and if eligible, were randomized to metformin /day) or placebo.
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