The benefit-risk of the mRNA-1273 COVID-19 vaccine medrxivpreprint US_FDA mRNA vaccine vaccination COVID19 coronavirus covid SARSCoV2
By Tarun Sai LomteDec 12 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers modeled the benefit-risk of Moderna’s coronavirus disease 2019 mRNA-1273 vaccine.
The study and findings In the present study, researchers performed the benefit-risk assessment of the mRNA-1273 vaccine in individuals aged 18 or above. They evaluated the benefits and risks per million individuals stratified by age, given the age-dependent risk of pericarditis and myocarditis after vaccination. The benefit endpoints were COVID-19 cases, hospitalizations, and admissions to an intensive care unit preventable by vaccination.
The authors assumed SARS-CoV-2 Omicron as the dominant variant for five scenarios and 30% and 72% vaccine effectiveness against COVID-19 cases and hospitalization, respectively. For scenario 4, SARS-CoV-2 Delta was assumed as the predominant variant, and the VE was 80% and 90% against COVID-19 cases and hospitalizations.
The model predicted that vaccinating a million males aged 18 to 25 with two mRNA-1273 doses would have prevented 82,484 COVID-19 cases, 4,766 associated hospitalizations, 1,144 ICU admissions, and 51 deaths in the base scenario. Nonetheless, this would have resulted in 128 cases of myocarditis/pericarditis, with 110 hospitalizations and zero ICU admissions/deaths.
Notably, given the uncertainty in the pandemic trajectory, the assumption of a constant rate of COVID-19 incidence would have created a high uncertainty on benefit outcomes. The estimated benefits of COVID-19 vaccination will decline if the VE decreases against emergent SARS-CoV-2 variants.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
How the COVID-19 pandemic impacted the treatment pancreatic cancer patientsHow the COVID-19 pandemic impacted the treatment pancreatic cancer patients Cancer Coronavirus Disease COVID PancreaticCancer Pandemic medrxivpreprint OpenSAFELY UniOfSurrey UniofOxford ucl
Consulte Mais informação »
China ravaged by ‘wildfire’ Covid outbreak after Xi's humiliating climbdownCHINA has been hit by Covid outbreak that will spread like “wildfire” after the country abandoned its harsh lockdown. Xi Jinping was forced to abandon his ‘Zero Covid’ policy after a wa…
Consulte Mais informação »
Severe COVID-19 causes aging-like changes in the human brainSevere COVID-19 causes aging-like changes in the human brain Aging Brain Coronavirus Disease COVID Neurology harvardmed BIDMChealth BrighamWomens NatureAging
Consulte Mais informação »
China warned to accelerate approval of updated jabs to tackle Covid ‘tsunami’\n\t\t\tKeep abreast of significant corporate, financial and political developments around the world.\n\t\t\tStay informed and spot emerging risks and opportunities with independent global reporting, expert\n\t\t\tcommentary and analysis you can trust.\n\t\t
Consulte Mais informação »