Severe COVID-19 causes aging-like changes in the human brain Aging Brain Coronavirus Disease COVID Neurology harvardmed BIDMChealth BrighamWomens NatureAging
By Neha MathurDec 11 2022Reviewed by Benedette Cuffari, M.Sc. In a recent article published in Nature Aging, researchers found that severe coronavirus disease 2019 triggers aging-like changes in the brain's frontal cortex region, resulting in cognitive deficits. These findings highlight the importance of neurological examination of individuals who have recovered from COVID-19.
Despite these observations, there remains inadequate molecular evidence for severe acute respiratory syndrome coronavirus 2 -induced effects on the brain, which the researchers of the current study have hypothesized are similar to accelerated aging effects. The team identified frontal cortex samples whose whole-transcriptome analysis yielded DEGs with a false discovery rate of less than 0.05 for gene-set enrichment analysis . To reduce bias in transcriptome profiling methods, an 'aging index' was devised using the aging and control cohorts as a training and test set.
Related StoriesAnother independent control cohort comprised of nine SARS-CoV-2-uninfected people between 22 and 85 years old with a history of ventilator or intensive care unit treatment was also included in the final analysis. Study findings Except for the 62-year-old individual with epilepsy and the 23-year-old with asymptomatic infection, all COVID-19 cases in the aging cohort were segregated farther from controls, as assessed by clustering analyses. Aged adults in the ICU/VENT cohort also clustered near SARS-CoV-2-infected individuals in the aging cohort.
Additional analyses leveraging the aging index confirmed that severe COVID-19 shifted the molecular age of brains relative to uninfected ICU/VENT and age- and gender-matched controls.
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