Older cells may fail to make proteins or may make proteins that don't function as they should, in a discovery that could lead to new drug targets to slow the ageing process
To uncover a potential link between impaired gene expression and senescent cells in people, Sen and her colleagues took cultured lung cells from a donated human fetus and made them divide so frequently that they became senescent in three months, mimicking the ageing process.
The team then used a sequencing method called PRO-cap to analyse the lengths of newly formed RNA transcripts, which make proteins in a cell from a gene’sThe researchers found that these fetal senescent cells gave rise to very short RNA transcripts. These may then fail to make proteins or may make proteins that don’t act as they should, says Sen, who hopes to investigate this further in the future.to ageing, but we don’t know what is going on, says Sen.
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