Desmoplastic melanoma, an often deeply invasive disease occurring in older adults, showed a uniquely favorable response to neoadjuvant pembrolizumab in this small study.
March 29, 2023
"I am unaware of any other therapy that produces such a high response rate in the neoadjuvant setting in this group of patients," she said, noting that the majority of patients in this small study had primary or recurrent disease. None of the patients were prevented from receiving surgery owing to disease progression or metastasis. Of the 26 patients who received wide excision of their primary or recurrent disease, 21 had no residual, viable tumor at the site on final pathology.
With a median follow-up of 24 months, two local recurrences were reported, each occurring in patients who did not have a pathologic complete response.
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