Researchers say the results suggest that long-term use of methylphenidate is effective. However, some patients should be assessed regularly to determine whether they still have a need for methylphenidate or may function well without it.
was administered to participants, or they were administered gradual withdrawal over three to four weeks with use of a placebo.
At the study’s culmination, researchers used common ADHD rating scales to compare symptoms before and after the seven-week period. They found that patients who discontinued treatment saw worsening symptoms while those who continued takingexperienced uninterrupted symptom control, even after two years or more of treatment with methylphenidate.
Continuation and discontinuation groups had average ADHD-RS scores at baseline of 21.4 and 19.6 , respectively. The average scores were 21.9 and 24.7 after 7 weeks. Between groups, the difference in change over time was −4.6 , favoring the methylphenidate group. Also, The ADHD-RS inattention subscale and the CTRS-R:S ADHD index and hyperactivity subscale deteriorated substantially more in the discontinuation group. 40.
Researchers say the results suggest that long-term use of methylphenidate is effective, however some patients should be assessed regularly to determine whether they still have a need for methylphenidate or may function well without it.Anne-Flore M. Matthijssen, et al. Continued Benefits of Methylphenidate in ADHD After 2 Years in Clinical Practice: A Randomized Placebo-Controlled Discontinuation Study.
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