Study confirms efficacy of molnupiravir against COVID in a real-life cohort

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Study confirms efficacy of molnupiravir against COVID in a real-life cohort
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Study confirms efficacy of molnupiravir against COVID in a real-life cohort antiviral treatment COVID molnupiravir SARSCoV2 wileymicrobio UniSassari

By Dr. Priyom Bose, Ph.D.Jul 26 2022Reviewed by Benedette Cuffari, M.Sc. Since the onset of the coronavirus disease 2019 pandemic caused by the severe acute respiratory syndrome coronavirus 2 , over 6.38 million deaths and 572 million infections have been reported.

Background Some of the common symptoms associated with COVID-19 include cough, fever, gastrointestinal disorders, dyspnea, headache, as well as loss of smell and taste. In some cases, individuals who experience severe COVID-19 may suffer life-threatening systemic inflammation, multiorgan dysfunction, and respiratory failure.

One of the key advantages of molnupiravir for the treatment of COVID-19 is that it can be easily administered at home. Other COVID-19 therapeutics, such as monoclonal antibodies and remdesivir, require hospital settings to be administered. The study cohort included adult participants diagnosed with COVID-19, which was confirmed by the reverse transcription-polymerase chain reaction assay. These patients were subjected to a five-day treatment course with molnupiravir according to the Italian Agency for Drugs guidelines.

During follow-up, 10.4% of participants exhibited disease progression. Notably, neurodegenerative disorders were associated with an increased risk of COVID-19 progression.

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