Lower fecal concentrations of the three major short-chain fatty acids are associated with a higher risk and incidence of colorectal cancer, according to systematic review and meta-analysis published in BMCMedicine.
] to systematically search and extract data from primary human studies with SCFA measurement in CRC risk or incidence.The Medline, Embase, and Web of Science database search was performed for articles involving human subjects that are in English from database conception until June 29, 2022. The details of the search keywords and strategies utilized in Ovid and Web of Science are available in the Additional fileAll the records, including abstracts, were imported to EndNote X9 .
The records were then filtered using EndNote’s built-in search tool for the following criteria: searching for concentration*, level*, quanti*, measure*, assess*, evaluat*, estimat*, calculat*, mmol, and μmol as the inclusion criteria to capture studies which reported the SCFA measurement based on these terms, and searching for mouse, mice, murine, rats, conference, ethyl acetate , and phorbol as the exclusion criteria to exclude rodent studies, conference proceedings, and studies that have...
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