Serum amyloid A (SAA) is a family of ancient proteins that can be traced from present-day humans back half a billion years to sea cucumbers and oysters. A new study by researchers from the Boston University Chobanian & Avedisian School of Medicine explores the link between the dual nature of this small plasma protein: how it works to clear toxic debris from wounds and inflammation sites, but also its role in forming fibrous deposits of the pathologic amyloid in vital organs such as the kidney and liver in the life-threatening disease AA amyloidosis.
detergent more potent than bile," said Shobini Jayaraman, Ph.D., senior staff scientist in pharmacology, physiology & biophysics and the lead author of this study.
"This finding solidifies our theory that SAA clears cell membrane debris from the sites of injury and inflammation in animals and humans," said Olga Gursky, Ph.D., professor of pharmacology, physiology & biophysics, the senior author of the study and the principal investigator on the NIH grant that supports this research.
The study found that secretory phospholipase A2, an inflammatory enzyme that raises in blood together with SAA and acts synergistically with it in removing cell membrane debris, can also promote SAA amyloid deposition, said Jayaraman. The dual nature of proteins that both transport lipids and form amyloids is present in other diseases, like Alzheimer's amyloid-beta peptide. Apolipoprotein A-I, the major protein in"good cholesterol," can also form pathologic amyloids resulting in atherosclerosis and systemic amyloidosis, said Gursky.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
How to stay safe exploring Pennsylvania State Parks and Philly trailsFrom how to identify snakes to how to protect yourself from mosquitos and ticks.
Consulte Mais informação »
Goldman Sachs is exploring sale of investment advisory unit - reports By Investing.comGoldman Sachs is exploring sale of investment advisory unit - reports
Consulte Mais informação »
Exploring Cosmic Extremes: The Unusual Jet Structure of the Brightest of All Time Gamma-Ray BurstResearchers studying GRB 221009A, the Brightest of All Time (BOAT) gamma-ray burst, found its jet exhibited an unusual structure, which may explain its extreme nature and prolonged visible afterglow. These findings could challenge standard theories about gamma-ray bursts and shape future studies.
Consulte Mais informação »
Exploring Seasonality in Wall Street, Europe, and Asia-Pacific Stock MarketsHave you ever wondered whether certain months are better or worse for stock markets? While we can identify meaningful seasonality, by itself, it is a poor predictor of past performance.
Consulte Mais informação »
The Beauty Products Sarah Feingold Uses to the Last DropIS Clinical serum, MAC lip liner, and more.
Consulte Mais informação »
This Sold-Out Growth Serum For Perfect Lashes And Brows Is Finally Back In StockI'm about to save SO much cash on lash lifts, extensions and mascara.
Consulte Mais informação »