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Russia admits ‘problems’ as energy revenues fall\n\t\t\tExpert insights, analysis and smart data help you cut through the noise to spot trends,\n\t\t\trisks and opportunities.\n\t\t\n\t\tJoin over 300,000 Finance professionals who already subscribe to the FT.
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Saudi Aramco’s Disappointing Earnings Are The Least Of Its Problems | OilPrice.comSaudi Aramco’s 19% drop in net income may be bad news for the company but, following its IPO, there are much greater risks for the Saudi oil giant
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Sex differences in the polygenic architecture of hearing problems in adults - Genome MedicineBackground Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predisposition. Although several risk loci have been already identified, HP biology and epidemiology are still insufficiently investigated by large-scale genetic studies. Methods Leveraging the UK Biobank, the Nurses’ Health Studies (I and II), the Health Professionals Follow-up Study, and the Million Veteran Program, we conducted a comprehensive genome-wide investigation of HP in 748,668 adult participants (discovery N = 501,825; replication N = 226,043; cross-ancestry replication N = 20,800). We leveraged the GWAS findings to characterize HP polygenic architecture, exploring sex differences, polygenic risk across ancestries, tissue-specific transcriptomic regulation, cause-effect relationships with genetically correlated traits, and gene interactions with HP environmental risk factors. Results We identified 54 risk loci and demonstrated that HP polygenic risk is shared across ancestry groups. Our transcriptomic regulation analysis highlighted the potential role of the central nervous system in HP pathogenesis. The sex-stratified analyses showed several additional associations related to peripheral hormonally regulated tissues reflecting a potential role of estrogen in hearing function. This evidence was supported by the multivariate interaction analysis that showed how genes involved in brain development interact with sex, noise pollution, and tobacco smoking in relation to their HP associations. Additionally, the genetically informed causal inference analysis showed that HP is linked to many physical and mental health outcomes. Conclusions The results provide many novel insights into the biology and epidemiology of HP in adults. Our sex-specific analyses and transcriptomic associations highlighted molecular pathways that may be targeted for drug developme
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New York council leader aims to tackle city's renting problemsLabour leader Claire Douglas says she wants to improve 'disheartening' council homes.
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Market Rasen councillor calls for quicker flood prevention actionCalls for quicker action to solve Lincolnshire's flooding problems
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Star Wars Jedi: Survivor gets a new patch on PC todayPatch 5 takes on another handful of PC-specific issues, and dozens more multiplatform problems.
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