Study pinpoints why some adults develop hearingproblems yale
This research was performed using the UKB Resource under the application 58146. UKB has approval from the North West Multi-center Research Ethics Committee as a Research Tissue Bank approval. This approval means that separate ethical approval is waived and that researchers can operate under the RTB approval. The use of MVP individual-level data was conducted under project #MVP010. MVP is approved by the VA Central IRB, and project #MVP010 was also approved by local VA IRB in San Diego.
Association of the hearing-problem polygenic risk score derived from the UKB-NHS-HPFS sex-combined meta-analysis in the MVP cohort.Association of the hearing-problem polygenic risk score derived from the UKB-only sex-combined GWAS in the NHS-HPFS combined sample.Association of the hearing-problem polygenic risk score derived from the UKB-only female-specific GWAS in the NHS sample.
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Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing - Genome MedicineEpigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a strategy using nanopore-based single-molecule sequencing to measure cfDNA methylomes. This approach generated up to 200 million reads for a single cfDNA sample from cancer patients, an order of magnitude improvement over existing nanopore sequencing methods. We developed a single-molecule classifier to determine whether individual reads originated from a tumor or immune cells. Leveraging methylomes of matched tumors and immune cells, we characterized cfDNA methylomes of cancer patients for longitudinal monitoring during treatment.
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Pregnancy and oral health: Unveiling the risks and awareness for mothers-to-beStudy examines the impact of pregnancy on oral health, including increased risks of gum disease and tooth decay. It also investigates women's self-assessment of oral health, health literacy, and awareness of the oral health-pregnancy connection.
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SIMplyBee: an R package to simulate honeybee populations and breeding programs - Genetics Selection EvolutionBackground The Western honeybee is an economically important species globally, but has been experiencing colony losses that lead to economical damage and decreased genetic variability. This situation is spurring additional interest in honeybee breeding and conservation programs. Stochastic simulators are essential tools for rapid and low-cost testing of breeding programs and methods, yet no existing simulator allows for a detailed simulation of honeybee populations. Here we describe SIMplyBee, a holistic simulator of honeybee populations and breeding programs. SIMplyBee is an R package and hence freely available for installation from CRAN http://cran.r-project.org/package=SIMplyBee . Implementation SIMplyBee builds upon the stochastic simulator AlphaSimR that simulates individuals with their corresponding genomes and quantitative genetic values. To enable honeybee-specific simulations, we extended AlphaSimR by developing classes for global simulation parameters, SimParamBee, for a honeybee colony, Colony, and multiple colonies, MultiColony. We also developed functions to address major honeybee specificities: honeybee genome, haplodiploid inheritance, social organisation, complementary sex determination, polyandry, colony events, and quantitative genetics at the individual- and colony-levels. Results We describe its implementation for simulating a honeybee genome, creating a honeybee colony and its members, addressing haplodiploid inheritance and complementary sex determination, simulating colony events, creating and managing multiple colonies at the same time, and obtaining genomic data and honeybee quantitative genetics. Further documentation, available at http://www.SIMplyBee.info , provides details on these operations and describes additional operations related to genomics, quantitative genetics, and other functionalities. Discussion SIMplyBee is a holistic simulator of honeybee populations and breeding programs. It simulates individual honeybees with their genom
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Twisted 'Toy-Box Killer' trapped victims in sex dungeon and 'murdered 50 women'IN A remote town in the middle of the desert, a twisted sexual sadist dubbed the “Toy-Box Killer” raped and murdered potentially more than 60 women in a depraved series of crimes. David…
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