Researchers demonstrate that neutralizing antibody titers wane over time in ChAdOx1, BNT162b2 and mRNA-1273 vaccinees JIDJournal imed_tweets antibody vaccine vaccination COVID19 coronavirus covid SARSCoV2
By Dr. Chinta SidharthanNov 10 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in The Journal of Infectious Diseases, a team of researchers from Austria investigated the neutralization antibody titers and the efficacy of the humoral and cellular immunities in individuals vaccinated with three coronavirus disease 2019 vaccines — the adenoviral vector vaccine ChAdOx1, and the two messenger ribonucleic acid vaccines mRNA-1273 and BNT162b2.
About the study In the present study, the team obtained serum samples and peripheral blood mononuclear cells from 109 uninfected individuals vaccinated with two doses of the adenoviral vector vaccine ChAdOx1 or either of the two mRNA vaccines mRNA-1273 and BNT162b2. The samples were collected one month and six months after vaccination. The participants were, on average, 42.8 years old, with 57.8% females and 42.2% males.
Results The results reported that the highest levels of anti-SARS-CoV-2 specific IgG were detected in individuals immunized with either of the two mRNA vaccines one month after dose two. In the samples collected six months after the second dose, the antibody levels were lowest for individuals vaccinated with ChAdOx1, and the antibodies induced by the mRNA vaccines were five times higher in comparison.
Against the Omicron BA.1 subvariant, only the ChAdOx1 vaccinated group displayed neutralization capacity above the cut-off, with an NT50 value of 34.4 at six months following dose two. In contrast, only the mRNA-1273 vaccinated group displayed effective neutralizing ability against the BA.2 subvariant one month after dose two, and none of the vaccination groups displayed any neutralization against BA.2 six months after dose two.
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