Portable SARS-CoV-2 Sensor Using Freestanding Laser-Induced Graphene ACS_AMI viral sensor SARSCoV2 COVID19
By Bhavna KavetiSep 14 2022Reviewed by Susha Cheriyedath, M.Sc. Early diagnosis of an infectious viral disease can help the patients and health care professionals monitor the outbreaks accurately and provide treatment at the early stage of a disease, avoiding any detrimental consequences. The accuracy of information is essential while monitoring such diseases to prevent any possible pandemics.
Additionally, a protocol was developed for aqueous biological sensing of SARS-CoV-2 spike proteins. Herein, the device was functionalized with coronavirus disease 2019 antibodies, and the wetting dynamic response of graphene sensors was characterized in buffer solution and water. Moreover, the designed device could specifically detect SARS-CoV-2 spike protein.
In most fabrication techniques, the laser-induced graphene remains embedded in the substrate, whose removal requires scraping, which either destroys the material’s structure or delaminates into the polymer and disturbs the morphology of the fabricated surface. In the present study, a FLIG-based resonator was built as a resonative sensor with miniaturized dimensions along with high sensitivity and selectivity toward SARS-CoV-2 spike proteins and their quantification. The FLIG was functionalized with SARS-CoV-2 spike protein antibodies using a pyrene-containing linker that binds strongly to graphene and laser-induced graphene materials.
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