Nirmatrelvir–ritonavir found to lower COVID-19 severity outcomes CMAJ UofT Nirmatrelvir Ritonavir COVID19 SARSCoV2 Outcomes
By Pooja Toshniwal PahariaFeb 16 2023Reviewed by Aimee Molineux In a recent study published in the Canadian Medical Association Journal, researchers evaluated the effectiveness of nirmatrelvir–ritonavir in preventing coronavirus disease 2019 severity outcomes during the severe acute respiratory syndrome coronavirus 2 Omicron variant predominance.
Per the trial findings, several studies have reported that the drug combination conferred significant protection against severe SARS-CoV-2 infection in individuals, especially those aged ≥65 years. On the contrary, the trial among standard-risk individuals clinical trial documented non-significant findings.
The study comprised Ontario residents aged >17.0 years, with SARS-CoV-2-positive polymerase chain reaction reports, between 4 April and 31 August 2022. COVID-19-associated hospitalizations and any-cause deaths within 30.0 days of the index date , were evaluated among Individuals treated with nirmatrelvir-ritonavir and untreated patients.
Data on COVID-19-associated hospitalizations were obtained from the case and contact management database and mortality data were obtained from the registered persons’ database, in addition to the case and contact management database. Data on comorbidities were obtained from the Ontario Health Insurance Plan and Canadian Institute for Health Information databases.
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