How does previous diet impact the endocannabinoidome and microbiome response to a short-term Mediterranean diet intervention? universitelaval diet microbiome health healthy food guthealth gutmicrobiome
By Bhavana KunkalikarFeb 15 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Microbiome, researchers assessed the different impacts of diet on the gut microbiome.
About the study In the present study, researchers determined the impact of a lead-in diet on the participants' response to a 48-hour MedDiet intervention. The participants were asked to consume the foods and beverages that the study provided, matching their calculated energy requirements. Each subject's energy requirements were estimated by averaging the energy demands assessed using a validated web-based 24-hour dietary recall . The R24W was performed on three separate events, and the energy expenditure was estimated using the Harris-Benedict formula. The healthy eating index was also derived using the R24W.
The first MedDiet intervention did not have a significant impact on short-chain fatty acids and branched CFAs . On the other hand, valerate, propionate, isobutyrate, and isovalerate increased significantly after the CanDiet and subsequently dropped after the second MedDiet. There was no significant difference between the amounts of bioactive lipids in MedDiet at V2 and V4. However, analysis of V4 suggests that diet stabilization enhanced the metabolite response reproducibility.
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