New study provides comparison of replicating and non-replicating vaccines against SARS-CoV-2 MayoClinic SARSCoV2 COVID19 Pandemic ReplicatingVaccine NonReplicatingVaccine Vaccination
By Nidhi Saha, BDSAug 26 2022Reviewed by Aimee Molineux Coronavirus disease 2019 , the pandemic caused by the severe acute respiratory syndrome coronavirus 2 , infected millions globally. The high mortality of COVID-19 warranted an immediate preventive measure. Out of all the available vaccine technology, mRNA vaccines were first approved by the United States Food and Drug Administration .
It was found that in human cells, there is 100,000-fold replication of the human Ad6 genome. There lies a similarity between the DNA replication of SC-Ad and RC-Ad. Further, it was observed that in contrast to mice, Syrian hamsters permitted AD6 infection, although the replication is less than human cells by a factor of at least ten.
An assay of week six sera was done for neutralizing antibodies which revealed significant inhibition by the SC-Ad-spike, both via IM and IN routes, following single immunization. However, no significant spike receptor-binding domain was seen in the RD-Ad-vaccinated hamsters. Related StoriesFollowing IN immunization, the animals were monitored for seven days. The results showed that controls vaccinated with RD-Ad-GL lost up to 15% body weight by the sixth day, whereas animals immunized with RD-Ad-spike lost lesser weight. A significant difference was found between the RD-Ad-Spike group and the SC-Ad-Spike group immunized by IM route on days five and six; the latter had relatively lesser weight loss.
As SC-Ads had better long-term viral protection, it was further implored for effects following the vaccination for different routes of administration. Phosphate–buffered saline was used to immunize five male hamsters via IN or IM route, who were subsequently challenged after six weeks.
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