Neither 'new' nor convincing is the conclusion of epidemiologist Christopher Labos' review of the COSMOS studies on multivitamins (and chocolate) to forestall dementia and CVD.
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit.and its finding that multivitamins did not improve brain or cardiovascular health. So I was surprised to read that a"new" study found that vitamins can forestall dementia and age-related cognitive decline.definitive study on chocolate that would establish its heart-health benefits without a doubt.
COSMOS-Mind is often described as a separate study. In reality, it included the same participants from the original COSMOS trial and measured yet another primary outcome of cognitive performance on a series of tests administered by telephone. Although there is nothing inherently wrong with studying multiple outcomes in your patient population , they cannot all be primary outcomes. Some, by necessity, must be secondary hypothesis–generating outcomes.
A more salient question is: What does a 0.07-point improvement on the z-score mean clinically? This study didn't assess whether a multivitamin supplement prevented dementia or allowed people to live independently for longer. In fairness, that would have been exceptionally difficult to do and would have required a much longer study.
COSMOS-Web was a positive study in that patients getting the multivitamin supplement did better on the test for immediate memory recall , though they didn't improve on tests of memory retention, executive function, or novel object recognition . They were able to remember an additional 0.71 word on average compared with 0.44 word in the placebo group. .
Do enough tests in the same population, and something will rise above the noise just by chance. When you get a positive result in your research, it's always exciting. But when a slew of studies that came before you are negative, you aren't groundbreaking. You're an outlier.
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