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Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk - BMC MedicineBackground Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships are causal, and whether the risk factors act independently of each other. The aim of this study was to investigate putative causal relationships between the number of live births, age at last live birth, and years ovulating and EC risk. Methods We conducted a series of observational analyses to investigate various risk factors and EC risk in the UK Biobank (UKBB). Additionally, multivariate analysis was performed to elucidate the relationship between the number of live births, age at last live birth, and years ovulating and other related factors such as age at natural menopause, age at menarche, and body mass index (BMI). Secondly, we used Mendelian randomization (MR) to assess if these observed relationships were causal. Genome-wide significant single nucleotide polymorphisms (SNPs) were extracted from previous studies of woman’s number of live births, age at menopause and menarche, and BMI. We conducted a genome-wide association analysis using the UKBB to identify SNPs associated with years ovulating, years using the contraceptive pill, and age at last live birth. Results We found evidence for a causal effect of the number of live births (inverse variance weighted (IVW) odds ratio (OR): 0.537, p = 0.006), the number of years ovulating (IVW OR: 1.051, p = 0.014), in addition to the known risk factors BMI, age at menarche, and age at menopause on EC risk in the univariate MR analyses. Due to the close relationships between these factors, we followed up with multivariable MR (MVMR) analysis. Results from the MVMR analysis showed that number of live births had a causal effect on EC risk (OR: 0.783, p=0.036) independent of BMI, age at menarche and age at menopause. Conclusions MVMR analysis showed that the number of live births causally reduced the ri
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Referee appointed for Hornets' date with RoyalsJames Linington has been appointed to take charge of Watford’s last game at Vicarage Road before the World Cup break when they face Reading…
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Double suspensions hinder Watford but Cathcart and Kalu returnFrancisco Sierralta and Hassane Kamara miss tomorrow night’s home game with Reading at Vicarage Road due to suspension
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Gridlock by Watford and St Albans due to M25 protests - list of routes affectedPolice have confirmed the M25 is now back open in Hertfordshire following a protest by Just Stop Oil. However, there are major delays near Watford, St Albans, and Potters Bar which could take some time to clear.
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Change of Sporting Director at Watford could happen this monthIt’s understood Watford have approached Eintracht Frankfurt to speak to Ben Manga as they look to replace Sporting Director Cristiano Giaretta
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Watford boss Bilic has faced Reading's 'Guv'nor' beforeWatford head coach Slaven Bilic has faced Reading manager Paul Ince - known as 'The Guv'nor' - as a player
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