Ketogenic diet: A metabolic makeover boosting immunity and battling inflammation Ketogenic diet Tcell immunity metabolomics immunometabolism Westerndiet metaflammation ESPENorg
By Dr. Priyom Bose, Ph.D.May 8 2023Reviewed by Benedette Cuffari, M.Sc. Western dietary habits are known to cause many of today’s non-communicable diseases by promoting chronic inflammation. Recently, to counteract WD-induced metaflammation, ketogenic diets have emerged.
Study: A ketogenic diet substantially reshapes the human metabolome. Image Credit: nadianb / Shutterstock.com Comparatively, KD involves a minimal intake of carbohydrates and leads to the hepatic synthesis of ketone bodies, thereby providing a robust alternate source of energy to the body’s peripheral tissues. One type of ketone body known as β-hydroxybutyrate serves as a substrate for mitochondrial oxidative phosphorylation and leads to pleiotropic effects.
Related StoriesPrior to the start of the study, participants consumed a standard WD comprising about 55-60% carbohydrates, 25-30% fat, and 10-15% protein. In the KD, a maximum of 10% of the daily caloric intake was provided by carbohydrates, whereas the remaining diet consisted of 60-70% fat, 20-30% protein, and 10% carbohydrates.
The marked reduction of carbohydrates led to a reduction in both insulin and c-peptide levels, which may explain the moderate weight loss observed in the participants. It could not be confirmed whether the extent of weight loss correlated with the changes in serum metabolic parameters. During KD, high acylcarnitines imply a higher demand for long-chain fatty acids as substrates of β-oxidation. Using carnitine as a transport shuttle system, these substances must be transported into the mitochondrial matrix.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
High-fat diets' eye-opening impact: Study reveals link to retinal damage and bisretinoid accumulationIn this study, the effects of a high-fat diet on the formation of bisretinoids in photoreceptor cells were explored. The results showed that mice on a high-fat diet had increased levels of bisretinoids and retinol-binding protein 4, which are associated with metabolic dysregulation.
Consulte Mais informação »
I'm A Plant-Based Dietitian. This Is What I Want You To Know About Diet And FertilityThese six pointers can help optimise fertility.
Consulte Mais informação »
'Silent killer' high cholesterol risk cut with three food swaps, doctor saysHigh levels of cholesterol can lead to heart attacks, but making some changes to your diet can reduce the risk.
Consulte Mais informação »
Michael Mosley shares top foods for boosting metabolism and aiding weight lossThe expert has revealed what he does, in terms of diet and exercise, to improve his metabolic rate.
Consulte Mais informação »
Andy Murray produces stunning comeback to win first title in four yearsBREAKING: Andy Murray has lifted his first piece of silverware in four years with a comeback win over Tommy Paul in Sunday’s Open du Pays d’Aix final.
Consulte Mais informação »