How mRNA vaccines work without an added adjuvant Coronavirus Disease COVID Antibodies mRNA Antigen Cell Coronavirus Immunity ImmunityCP UGent UBC ChildrensPhila karolinskainst Penn
The nucleoside-modified mRNA vaccines used against coronavirus disease 2019 include BNT162b2 and mRNA-1273 . These nucleoside-modified mRNA- lipid nanoparticles containing ionizable lipids vaccines have shown high effectiveness at generating spike-specific adaptive immune responses, especially neutralizing antibodies for the induction of protective immunity against COVID-19.
Depending on the mRNA dose, the encoded protein, the iLNP type, and the method of mRNA-iLNP delivery, protein synthesis after mRNA-iLNP injection begins early and peaks rapidly after four to 24 hours before declining gradually. These events may extend for a couple of days or over a week. Spike-encoding mRNA and spike protein are detected in germinal centers present in the draining axillary LNs of vaccinated people for up to 60 days following the second mRNA-1273 or BNT162b2 vaccine dose.
Lab Diagnostics & Automation eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today Activated monocytes, DCs, and macrophages are among the essential cell types that cause mRNA-iLNP absorption, protein synthesis, and presentation of antigens in the lymphoid tissue to facilitate the adaptive immune response.
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