How a major COVID-19 outbreak occurred in a naïve and vaccinated population in Taiwan with a limited number of entry events medrxivpreprint COVID19 coronavirus covid Taiwan
By Pooja Toshniwal PahariaSep 29 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers explored the severe acute respiratory syndrome coronavirus 2 genome using high-throughput genome sequencing to provide novel insights into how the novel SARS-CoV-2 Omicron BA.2.3.7 variant enters and spreads among the otherwise naïve Taiwanese population.
The team analyzed 2,405 polymerase chain reaction -confirmed SARS-CoV-2-positive nasopharyngeal swab specimens from 2,339 persons. Blood samples were obtained from the coronavirus disease 2019 patients enrolled from the NTU-HCH , and SARS-CoV-2 ribonucleic acid was extracted, amplified by reverse transcription PCR analysis, and subjected to whole-genome sequencing analysis.
Results Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year.BA.2.3.7 was detected as the prime causative variant of the 2022 SARS-CoV-2 outbreak among Taiwanese communities. The 1966 complete-length sequences of Omicron were uploaded to the GISAID database enabling the identification of three signature BA.2.3.7 mutations, i.e.
Most of the pilot study samples obtained in 2021 were assigned the Alpha variant. A remarkable increase in Omicron BA.2.3.7 infections was observed from week 4 onwards, and BA.2.3.7 variant percentage was persistently high for ≥10 weeks. The number of S:G1251V-positive sequences steadily increased from week 6 onwards and plateaued in the tenth week . In the period between weeks 11 and 15, the ORF1a:T3224A proportion reduced, whereas the ORF1a:I1091T proportion concomitantly increased.
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