Exploring the contribution of COVID-19 prevention network to SARS-CoV-2 vaccine efficacy clinical trials COVID19 SARSCoV2 VaccineEfficacy ClinicalTrials JAMANetworkOpen thisisUIC
By Pooja Toshniwal PahariaJan 25 2023Reviewed by Aimee Molineux In a recent special communication report published in JAMA Network Open, researchers described the coronavirus disease 2019 prevention network and its contribution to clinical efficacy evaluations of COVID-19 vaccines in phase 3 trials.
About the special communication In the present study, researchers described CoVPN in assisting the coordinated execution of phase 3 clinical vaccine efficacy trials in developing COVID-19 vaccines. As a result of CoVPN’s efforts, the five clinical phase 3 trial sites included 16 nations across the Sub-Saharan regions of Africa, the United States, and South America, spanning over five continents. Additionally, in the US, sites of several NIAID-funded networks were included, such as the Native Nations, Veterans Affairs, and Defense department sites.
The SAP formulated by CoVPN statisticians collaborated with the coronavirus disease 2019 response team statistics to provide master-trial protocols for harmonized analyses and guided non-CoVPN trials. Moreover, the CoVPN statisticians had access to the findings of all five clinical trials, which provided an opportunity to answer questions that could not be answered by any of the individual studies.
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