Review on lateral flow test use spearheaded by SARS-CoV-2 pandemic natureportfolio ucl Harvard LateralFlowTest SARSCoV2 COVID19
By Pooja Toshniwal PahariaJan 23 2023Reviewed by Aimee Molineux In a recent review published in Nature Reviews Bioengineering, researchers assessed the changing landscape of lateral flow tests , and the development of next-generation LFTs based on lessons learnt from the severe acute respiratory syndrome coronavirus 2 pandemic.
The changing landscape of LFT diagnostics LFTs were initially used as radiological immunoassays and latex agglutination tests and enabled paper-based dipstick tests for urinary glucose quantification. Eventually, the tests were used for pregnancy-related, serological assessments and diagnosis of human immunodeficiency virus infections.
Pre-COVID-19 pandemic LFTs used HIV antibodies and targeted antigens and antibodies. The tests were used for self-testing, clinical diagnosis, and screening at homes, clinics, and community-based settings, using gold nanoparticles and latex beads, with manually captured results. During COVID-19, LFTs used SARS-CoV-2 antigens, and their use was expanded to surveillance efforts.
Multiplexing and using quantum- and nano-materials, nucleic-acid-based LFTs, machine learning, and CRISPR could improve LFT connectivity and accuracy.
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