Delay in consciousness in severe cases of COVID-19 may be caused by neural hibernation Coronavirus Disease COVID SARSCoV2 PNASNews MIT WeillCornell
Study: Protective down-regulated states in the human brain: A possible lesson from COVID-19. Image Credit: Jay Ondreicka / Shutterstock
Burst suppression is a brain electrical pattern characterized by a cycling of suppressed cerebral activity and bursts of cerebral activity of variable amplitude, duration, and waveform. It is considered to be a sign of neuroprotective activity. Severe COVID-19 patients exhibit comparable burst suppression to those experiencing prolonged unconsciousness following cardiac arrest.
Electroencephalography of the patients shows burst suppression. All of them eventually experience full cognitive and physical recovery. As mentioned by the scientists, burst suppression characterized by reduced brain metabolism plays an essential neuroprotective role in these patients. Related StoriesThe anoxic exposure increases the release of a neurotransmitter , which in turn causes a downregulation in neuronal and metabolic activities in the turtle brain. This highlights the link between anoxic exposure and the establishment of a neuroprotective state.
Prolonged unconsciousness following severe COVID-19 as a neuroprotective mechanism Anoxia-resistant turtles exhibit a protective downregulated brain state that helps reduce the brain energy demand during systemic metabolic stress caused by anoxia or extreme temperature. Such protective mechanisms might also be present in the human brain.
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