Women who use certain types of hormones after menopause still have an increased risk of developing breast cancer nearly 2 decades after they stop taking the pills, federal study suggests.
The main part of the study was stopped in 2002 when researchers surprisingly saw more heart problems and breast cancers among hormone users. Women were advised to stop treatment but doctors have continued to study them and have information on about two-thirds.
With roughly 19 years of followup, 572 breast cancers have occurred in women on hormones versus 431 among those on dummy pills. That worked out to a 29 percent greater risk of developing the disease for hormone takers. Still, it was a difference of just 141 cases over many years, so women with severe hot flashes and other menopause symptoms may decide that the benefits of the pills outweigh their risks, doctors say. The advice remains to use the lowest possible dose for the shortest time.“The hormones are stimulating the cells to grow” and it can take many years for a tumor to form and be detected, said Dr. C. Kent Osborne, a Baylor College of Medicine breast cancer expert.
Women are prescribed hormones in combination because taking estrogen alone raises the risk of uterine cancer. However, one-quarter of women over 50 no longer have a uterus and can take estrogen alone for menopause symptoms.
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