Phase 1 clinical trials are showing promising signs for a new drug that successfully reduced weight and fat mass in obese mice on a high-fat diet while not disrupting their appetite.
. The increase in GABA is what causes the GABRA5 neurons to slow down and stop working properly, leading to weight gain.
So the team thought that if increasing the activity of GABRA5 neurons reduces fat storage, then blocking astrocytes from producing GABA is a potential molecular target for treating obesity. That's where the promising new drug comes in. Called KDS2010, it inhibits the MAOB enzyme in reactive astrocytes, thereby blocking production of GABA and allowing GABRA5 neurons to function normally and promote weight loss.
KDS2010 treatment yielded remarkable results in obese mice. Their fat tissue metabolism increased, fat storage decreased, and they lost weight despite being fed a high-fat diet, without impacting the amount of food they ate. This study tested male mice only, so there may be more to learn in further research. We might know more soon enough, as a biotech company called Neurobiogen – which is affiliated with the research team – is currently undertaking Phase 1 clinical trials with KDS2010.
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