The Omicron XBB.1.5 subvariant which has been identified in more than 25 countries, including the US and UK, is the most transmissible yet, says WHO
It was originally detected in October 2022 and has now been identified in more than 25 countries, including the UK.
China's recent COVID-19 outbreak is predominantly led by the Omicron subvariants BA.5.2 and BF.7, which together account for 97.5% of all local infections. Dr Mike Ryan, the WHO's emergencies director, has said China's COVID data is not giving an accurate picture of the situation there and underrepresents the number of hospitalisations and deaths from the disease.
Last month, China narrowed its definition for classifying deaths as COVID-related, choosing only to count those involving pneumonia or respiratory failure.The WHO says deaths should be attributed to COVID if they result from a"clinically compatible illness" in a patient with a probable or confirmed infection - and no other unrelated cause of death is involved such as trauma.
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COVID booster shots cut Omicron transmission in closed environmentsIn a recent paper published in the journal Nature Medicine, researchers in the United States investigated the infectiousness of incarcerated individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infections in prisons, high-risk settings where transmission is intense.
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Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection OutcomesAge-related macular degeneration (AMD) has been implicated as a risk factor for severe consequences from COVID-19. We evaluated the genetic architecture shared between AMD and COVID-19 (critical illness, hospitalization, and infections) using analyses of genetic correlations and pleiotropy (i.e., cross-phenotype meta-analysis) of AMD (n=33,976) and COVID-19 (n ≥ 1,388,342) and subsequent analyses including expression quantitative trait locus (eQTL), differential gene expression, and Mendelian randomization (MR). We observed a significant genetic correlation between AMD and COVID-19 infection (rG=0.10, p=0.02) and identified novel genome-wide significant associations near PDGFB (best SNP: rs130651; p=2.4 × 10−8) in the pleiotropy analysis of the two diseases. The disease-risk allele of rs130651 was significantly associated with increased gene expression levels of PDGFB in multiple tissues (best eQTL p=1.8 × 10−11 in whole blood) and immune cells (best eQTL p=7.1 × 10−20 in T-cells). PDGFB expression was observed to be higher in AMD cases than AMD controls {fold change (FC)=1.02; p=0.067}, as well as in the peak COVID-19 symptom stage (11–20 days after the symptom onset) compared to early/progressive stage (0–10 days) among COVID-19 patients over age 40 (FC=2.17; p=0.03) and age 50 (FC=2.15; p=0.04). Our MR analysis found that the liability of AMD risk derived from complement system dysfunction {OR (95% CI); hospitalization=1.02 (1.01–1.03), infection=1.02 (1.01–1.03) and increased levels of serum cytokine PDGF-BB {β (95% CI); critical illness=0.07 (0.02–0.11)} are significantly associated with COVID-19 outcomes. Our study demonstrated that the liability of AMD is associated with an increased risk of COVID-19, and PDGFB may be responsible for the severe COVID-19 outcomes among AMD patients.
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Why do some people develop persistent lung sequelae after severe COVID-19?Clinical presentation following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from mild self-limiting illness to severe respiratory failure. Many studies have analyzed the early acute phases of coronavirus disease 2019(COVID-19), but few focused on the longer-term sequelae following infection.
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These Countries Are Imposing COVID-19 Restrictions on ChinaAs COVID-19 infections in China continue to rise, and as concerns grow over the reliability of the country’s reporting and sequencing of cases, more than a dozen countries have announced new entry restrictions on travelers arriving from China
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EU offers free Covid-19 vaccines to China to help curb outbreak\n\t\t\tKeep abreast of significant corporate, financial and political developments around the world.\n\t\t\tStay informed and spot emerging risks and opportunities with independent global reporting, expert\n\t\t\tcommentary and analysis you can trust.\n\t\t
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Underlying genetic cause for MIS-C complications after COVID-19 identifiedA recent Science journal study determined the underlying cause of MIS-C related to SARS-CoV-2 in some children. It hypothesized that monogenic inborn errors of immunity (IEI) is the primary reason for this condition. Identifying these inborn errors is expected to help elucidate the disease's cellular, molecular, and immunological basis.
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