Some countries are moving ahead with plans to offer a fourth dose of COVID-19 vaccine. But studies are raising questions about the potential advantages of this extra booster.
Staff volunteers queue to receive a fourth dose of the Pfizer COVID-19 vaccine at Sheba Medical Center in Israel on Dec. 27, 2021, as the hospital conducted a trial of a fourth jab of the vaccine. At this point, one thing about the pandemic is clear: The COVID-19 vaccines, even when followed by a booster, aren’t going to stop the coronavirus — or provide long-term protection from infections.
But that’s not to say that an additional dose is pointless in all circumstances. For older people or those at high risk, an extra dose may be needed to help maintain protection against severe disease, Regev-Yochay says. “A fourth dose probably does have a role in protecting against severe disease. I’ve seen preliminary data looking into that question.”In the new study, Regev-Yochay and her team gave about 300 health care workers a fourth shot, either Pfizer or Moderna.
Regev-Yochay and her colleagues conclude that the fourth dose restores some protection lost after the third shot but doesn’t boost immunity beyond that.
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