Which drug best reduces sleepiness in patients with OSA? sleepapnea
Although EDS is reported in 40%–58% of patients with OSA and can persist in 6%–18% despite PAP therapy, most non-sleep specialists may not be aware of pharmacologic options, said Pitre."I have not seen a study that looks at the prescribing habits of physicians for this condition, but I suspect that primary care physicians are not prescribing modafinil–armodafinil frequently for this, and less so for solriamfetol," he said.
Pitre was surprised at the magnitude of solriamfetol's superiority to modafinil–armodafinil but cautioned that solriamfetol has been shown to increase blood pressure in higher doses. It therefore must be prescribed carefully,"especially to a population of patients who often have comorbid hypertension," he said.
Some limitations of the analysis were that all trials were conducted in high-income countries . Moreover, 77% of participants were White, and 71% were male.Commenting on the findings for Medscape, Sogol Javaheri, MD, MPH, who was not involved in the research, said that they confirm those of prior studies and are"consistent with what my colleagues and I experience in our clinical practices.
Javaheri is associate program director of the sleep medicine fellowship at Brigham and Women's Hospital and assistant professor of Medicine at Harvard Medical School in Boston. While sleep medicine specialists are more likely than others to prescribe these medications,"any clinician may use these medications, ideally if they have ruled out other potential reversible causes of EDS," said Javaheri.
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