Plus, everything to know about the difference between BRCA1 and BRCA2.
, for women with an altered BRCA1 gene, the risk of developing ovarian cancer is 40 to 60 percent by age 85. For BRCA2 mutations, the risk for cancer of the ovary is also increased — between 16 and 27 percent by late age. For these women, additional screening may be necessary, though Smith noted that screening has not yet been shown to change overall survival., Smith says the general recommendation for BRCA mutation carriers is prophylactic removal of the ovaries and fallopian tubes .
Smith recommends that people with BRCA mutations should also have regular screenings of their skin and eyes to, along with GI surveillance to screen for pancreatic cancer, though she noted that pancreatic screening will be somewhat dependent on the family history as well. The most reliable way to prevent breast cancer for both BRCA mutations is to remove the breasts. “With prophylactic mastectomies, we reduce the risk by about 95 percent for breast cancer, so it’s very effective, but it’s a big decision,” Pilewskie says. “Since we often talk about breast reconstruction sometimes it’s more than one operation.”
"The optimal recommendations for screening and risk reduction really depend on the magnitude of risk."
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