Data suggest that early detection of certain gastrointestinal disorders could aid in identifying patients at risk of Parkinson's disease.
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit.The enteric nervous system , which is regarded as our second brain, is the part of the autonomic nervous system that controls the digestive tract. Housed along the entire length of the digestive tract, it is made up of more than 100 million neurons.
Numerous literature reviews mention that ENS lesions are responsible for gastrointestinal disorders observed in patients with Parkinson's disease. Tests on gastrointestinal autopsy and biopsy specimens have established that alpha synuclein clusters, which are morphologically similar to Lewy bodies in the CNS, are seen in the vagus nerve and in the ENS in most subjects with Parkinson's disease.
Appendectomy appeared to be protective, leading to additional speculation about its role in the pathophysiology of Parkinson's disease. Additional mechanistic studies are therefore needed to establish causality and confirm the gut-brain axis or the role of dysbiosis and of intestinal permeability problems.
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