What is the relation between COVID-19 vaccination and new POTS-related diagnoses? NatureCVR CedarsSinai BrighamWomens COVID19 coronavirus covid vaccination vaccine diagnosis cardiac cardiology coronavirus
By Pooja Toshniwal PahariaDec 14 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Nature Cardiovascular Research, researchers assessed the association between POTS and severe acute respiratory syndrome coronavirus 2 infections and coronavirus disease 2019 vaccinations.
About the study In the present study, researchers performed a sequence-symmetry analysis to investigate the relationship between SARS-CoV-2 vaccinations and novel POTS-associated diagnoses by evaluating the odds of POTS diagnosis 90 days before the initial vaccination/infection vs. 90 days following the vaccination/infection .
The primary outcomes were the diagnosis-specific odds of a new diagnosis occurring post-exposure vs. pre-exposure and the odds of acquiring a post-exposure new POTS diagnosis vs. a new CPC diagnosis. The main analysis was repeated with the second vaccine dose as the index study exposure and using cluster bootstrapping. Logistic regression modeling was performed, and the odds ratios were calculated. Furthermore, manual adjudication of a subset of 50 events was performed.
Similar findings were observed after repeating the analysis and considering the second vaccination as the index vaccination. The OR value of post-vaccination diagnoses of POTS-associated conditions vs. CPC conditions was 1.1, with comparable results obtained by clustered bootstrapping. Similar results were obtained after sex stratification, except that EDS was reported rarely among men compared to women .
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