The safety, timing, magnitude, and durability of the antidepressant psilocybin on patients with major depressive disorders.
By Dr. Chinta SidharthanSep 4 2023Reviewed by Lily Ramsey, LLM In a recent study published in the JAMA Journal, researchers reported the results of a randomized clinical trial that evaluated various clinical aspects, including the safety, timing, magnitude, and durability of the antidepressant psilocybin on patients with major depressive disorders.
However, due to a variety of factors, such as inadequate sample size, assessment of studies by unblinded raters, insufficient evaluation of the potential adverse effects of psilocybin use, and issues with study design, there is a lack of clarity on the efficacy of psilocybin use for treating major depressive disorders.
Related StoriesAdults between the ages of 21 and 64 who were medically healthy and met the diagnostic criteria for major depressive disorders, with at least one episode of a depressive disorder in the last two months, were recruited for the study. The examined primary outcome was the difference between the two groups in the MADRS score between baseline and day 43, which was assessed by the centralized rater.
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