Two large studies show vitaminD supplementation has no benefit — as low dose, high dose, or in the form of cod liver oil — in preventing COVID-19 or acute respiratory tract infections, regardless of whether individuals are deficient or not. MedTwitter
, and some observational studies have linked low 25-hydroxyvitamin D D) with more severe COVID-19; however, data on a possible protective effect of vitamin D supplementation in preventing infection have been inconsistent.
Supplementation with cod liver oil was also not associated with a reduced risk of any of the coprimary endpoints, including other acute respiratory infections. "The null findings of the studies should be interpreted in the context of a highly effective vaccine rolled out during both studies," Bergman writes.
With two recent large meta-analyses showing benefits of vitamin D supplementation to be specifically among people who are vitamin D deficient,"a pragmatic approach for the clinician could be to focus on risk groups" for supplementation, Bergman writes.
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