The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.
ahead of peer review. Protection against symptomatic infection is "essentially eliminated" for individuals vaccinated more than four months earlier. Boosters restore protection to about 48%, "which is similar to the protection of individuals with waned immunity against the Delta variant ," Kilpatrick said.
"Importantly, protection against severe disease is much higher" for all categories: recently vaccinated, waned, or boosted. "We estimated that protection against severe disease was 86% for recent mRNA vaccination against Omicron, 67% for waned immunity, and 91% following 3rd dose boosters," Kilpatrick said. "There are still no direct estimates of vaccine effectiveness for severe disease from any country yet, so our estimates cannot be compared to direct estimates yet.
Researchers analyzed survey responses from 28,356 adults ages 18 to 69 from across the UK who had previously had COVID-19, nearly one-quarter of whom had reported troublesome lingering symptoms. The likelihood that participants would report long COVID symptoms at least 12 weeks after infection fell by 13% after the first vaccine dose, the researchers reported onahead of peer review. It was unclear whether this improvement continued between the first and second doses.
Vaccines reduce the severity of illness by inducing T cells in the immune system to recognize and eliminate virus-infected cells. In 303 patients on immune-suppressing therapies for inflammatory bowel disease, researchers used a new molecular measurement tool to count the numbers of antiviral T cells induced by COVID vaccines.
Age, sex and specific immunotherapies might be associated with patients' T-cell response to the vaccines, but the bottom line is that antibody levels after vaccination do not necessarily predict T cell responses, his team said in a report posted onahead of peer review. Levels of antiviral T cells are not often measured, Braun said, leaving open important questions.
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