A drug candidate developed by researchers at the University of Tennessee Health Science Center for advanced metastatic castration-resistant prostate cancer is now in its first clinical trial.
Ramesh Narayanan, PhD, deputy director of the Center for Cancer Research and the Muirhead Endowed Professor in the College of Medicine at UTHSC, and Duane Miller, PhD, Professor Emeritus in the Department of Pharmaceutical Sciences at UTHSC, have worked for more than a decade on therapies involving the hormone receptors that influence cancer progression. Their drug candidate, a molecule designed as a treatment for advanced metastatic prostate cancer, is now in its first clinical trial.
Biopharmaceutical company Oncternal Therapeutics, Inc., holds the license for the drug candidate, an androgen receptor inhibitor dubbed ONCT-534, developed at UTHSC by Drs. Narayanan and Miller. On October 5, the company announced the first patient had received ONCT-534. On October 26, Oncternal disclosed that the FDA granted fast-track designation for ONCT-534, which could potentially accelerate the clinical development process.
One of the primary reasons for treatment failure or relapse is a mutation of the receptor protein for androgens. Enzalutamide works on one area of the receptor.
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