The research builds on previous discoveries made by OHSU, indicating that persistent use of cannabis could potentially impair male fertility in animal studies. This will aid in advising patients about the implications of THC consumption when planning for conception. Researchers from Oregon Health
A research team from Oregon Health & Science University confirmed that chronic usage of THC, the psychoactive ingredient in cannabis, significantly affects male fertility and reproductive outcomes in nonhuman primates. However, discontinuing THC use can partially reverse these effects, improving male reproductive health, with a suggested minimum abstinence period of four months for better fertility outcomes.
“It’s so important that we research, understand, and educate about the implications of THC on reproductive health, especially as use continues to increase among individuals of reproductive age and more states legalize cannabis,” said the study’s corresponding author Jamie Lo, M.D., M.C.R., associate professor of obstetrics and gynecology , OHSU School of Medicine, and Division of Reproductive & Developmental Sciences at the Oregon National Primate Research Center, or ONPRC.
In a model using nonhuman primates, researchers administered THC in progressive doses over a period of about seven months, looking specifically at changes to the tissue of the male subjects’ reproductive health organs and testes, as well as the quantity and quality of their sperm. Analyses showed that THC exposure caused a significant reduction in the size of the testes and impacted male productive hormones, both of which negatively impact overall fertility.
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